2 edition of Identification and kinetics of monocytes in normal rat blood. found in the catalog.
Identification and kinetics of monocytes in normal rat blood.
1974 by Second Department of Pathology, University of Helsinki in Helsinki .
Written in English
APROTININ: BIOCHEMISTRY AND CLASSICAL MECHANISMS OF ACTION. Aprotinin is a nonspecific serine protease inhibitor that has been used primarily as a hemostatic drug in cardiac surgery with CPB ().Current dosing regimens were established around plasma concentrations of aprotinin needed to achieve the inhibition of numerous serine proteases in the coagulation cascade (Tables 1 and 2). Angiogenesis, a natural phenomenon of developing new blood vessels, is an integral part of normal developmental processes as well as numerous pathological states in humans. The angiogenic assays are reliable predictors of certain pathologies in particular tumor growth, metastasis, inflammation, wound healing, tissue regeneration, ischemia, cardiovascular, and ocular : Imran Shahid, Waleed H. AlMalki, Mohammed W. AlRabia, Muhammad Ahmed, Mohammad T. Imam, Muhammed K. The question whether haematocrit values should be raised into the normal range has been a matter of debate (, ) as a randomised prospective long‐term multicentre study of patients with cardiac disease showed the 1‐ and 2‐yr mortality rates to be 7% higher in the normal haematocrit () than in the low haematocrit () by: FIGURE Utilization and reutilization of 59Fe-labeled hemoglobin solution in patients with anemia of chronic disease and in normal subjects. (Adapted from Haurani et al., with permission) FIGURE Mean serum iron concentration and iron-binding capacity plus or minus the standard deviation of nine patients undergoing cholecystectomy.
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Author(s): Syrén,Enni Title(s): Identification and kinetics of monocytes in normal rat blood/ by Enni Syrén.
Country of Publication: Finland Publisher: Helsinki. The effect of azathioprine on the kinetics of peripheral blood monocytes and peritoneal macrophages was studied in normal mice and in mice in which an inflammatory reaction was provoked.
The average duration of some phases of the cell cycle of monocyte precursors can be estimated indirectly from 3 HT labeling data of monocytes in the blood. If samples of blood are drawn at closely spaced periods after a pulse of 3 HT, the resulting labeling pattern in the rat (Whitelaw et al., ) and man (Meuret, ) resembles a series of overlapping by: Moreover, incubation of normal monocytes with AIDS serum or plasma induced CD16 expression which correlated with serum TGF-beta levels (r =P less than ) and was inhibited with a.
Blood Advances is a semimonthly medical journal published by the American Society of Hematology. It is the first journal to join the Blood family in 70 years and is a peer-reviewed, online only, open access journal.
Under the direction of founding editor-in-chief Robert Negrin, MD, Stanford University Medical Center, Stanford, CA, the inaugural issue debuted on Novem Abstract.
The similarities found between morphological, cytochemical, and functional characteristics of mononuclear phagocytes, combined with knowledge about the origin and kinetics of these cells, led to the concept of the mononuclear phagocyte system (MPS) (van Furth et al.
).Cited by: Abstract. The cytochemical demonstration of peroxidatic (PO) activity is often used in studies on monocytes and macrophages. This reaction makes it possible to distinguish between resident (= tissue) macrophages on the one hand and monocytes and monocyte-derived cells on the other, since resident macrophages have PO activity in the rough endoplasmic reticulum (RER) and the nuclear envelope Cited by: Publisher Summary.
This chapter describes methods for the isolation and in vitro maintenance of human blood monocytes. The methods have been designed to produce a pure population of blood monocytes in suspension form derived from between 10 and ml of blood and to allow the culturing of the cells for periods up to four months.
Ensembl ENSG ENSMUSG UniProt Q Q80TL1 Q3V1Q3 RefSeq (mRNA) NM_ NM_ RefSeq (protein) NP_ NP_ Location (UCSC) Chr 5: – Mb Chr – 69 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Adenylyl cyclase type 2 is an enzyme typically expressed in the brain of humans, that is encoded by Aliases: ADCY2, AC2, HBAC2, adenylate cyclase 2.
Effect of IL on cytokine production. To study the effect of exogenous IL on IL-1β, IL-6, IL (p40), and TNF-α production, THP-1 cells were stimulated with 1 μg of L-OspA or LPS per ml in the presence or absence of various concentrations (,1, 10, and ng/ml) of human Cited by: Transplantation of CMP gave rise to all myeloerythroid but not any lymphoid progeny (except for rare B cells), while MEP gave only red cells and platelets, and GMP gave rise only to granulocytes, monocytes, and cells of the macrophage lineage, as well as all types of dendritic cells.
37,50, –55 In these studies it was shown that the day 7 Cited by: ALOX15 (also termed arachidonate lipoxygenase, lipoxygenase-1, LO-1, LOX-1) is, like other lipoxygenases, a seminal enzyme in the metabolism of polyunsaturated fatty acids to a wide range of physiologically and pathologically important products.
Gene Function. Kelavkar and Badr () stated that the ALOX15 gene product is implicated in antiinflammation, membrane remodeling, and Aliases: ALOX15, LOX, LOX-1, 15LOX-1. The identification of various subsets of monocytes has allowed researchers to address the in vivo rele vance of human monocytes by studying mouse monocytes.
Inflammation, trauma and immune stimuli all cause an increased recruitment of monocytes to peripheral tissues, aiding in host defense and tissue repair (Taylor, Martinez-Pomares et al.
O'Keeffe, M. et al. Dendritic cell precursor populations of mouse blood: identification of the murine homologues of human blood plasmacytoid pre-DC2 and CD11c + Cited by: Macrophages are part of the innate immune system, recognizing, engulfing, and destroying many potential pathogens including bacteria, pathogenic protozoa, fungi, and helminths.
The destructive potential of macrophages and their ability to secrete regulators of the function of neighboring cells contribute to many aspects of homeostasis. This chapter talks about the origins, differentiation, and Cited by: Kinetics of appearance of endoglin on monocytes.
(A) Normal PBMCs from 60 ml of blood were equally divided for three analyses. Monocytes were separated from lymphocytes by adherence to plastic, then further activated by incubation in culture. Total time in culture is by: Aim: To determine the characterisation of hyalocytes: the origin, phenotype, and turnover in the rodent.
Methods: To characterise the ultrastructure and distribution of hyalocytes, transmission and scanning electron microscopy was performed in rat eyes. Immunophenotypical analysis was performed by either anti-ED1 or ED2 antibodies.
To examine the origin of the hyalocytes, the chimeric mice Cited by: With Zanvil Cohn (–), van Furth identified blood monocytes as the precursors for tissue macrophages and bone marrow as the source of monocytes.
Invan Furth published a far more elaborated figure depicting the origin and kinetics of mononuclear phagocytes and the nature of the involved hematopoietic by: 4. Information Related to Biologic Plausibility.
The committee reviewed all relevant experimental studies of 2,4-dichlorophenoxyacetic acid (2,4-D), 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), 4-amino-3,5,6-trichloropicolinic acid (picloram), dimethylarsinic acid (DMA, also called cacodylic acid), and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) that have been published since Update (IOM.
Here we demonstrate that uninfected human peripheral blood monocytes, but not B or T cells, are the cells that transcribe the IL cytokine gene in response to heat-killed B. burgdorferi. burgdorferi similarly induced an upregulation of the IL-1β and IL-6 cytokine genes in monocytes and the production of IL and IL-6 in culture Cited by: Particles used for injection are liposomes, Monastral blue, microspheres, rabbit blood, rat blood and goat blood.
Data f 33,The pattern in species-specific. The blood-nerve barrier (BNB), formed by tight junction-forming microvessels within peripheral nerve endoneurium, exists to regulate its internal microenvironment essential for Cited by: Bone marrow precursors give rise to the monocytes in the blood, which circulate for a few days before they migrate into the tissue and mature.
Monocytes are recruited by cytokines and chemotactic factors, released by resident macrophages and neutrophils. In general, monocytes reach maximum numbers hours after by: Changes in the properties of normal human red blood cells during in vivo aging.
Franco RS, Puchulu-Campanella ME, Barber LA, Palascak MB, Joiner CH, Low PS, Cohen RM. Am J Hematol (). Identification of the components of a glycolytic enzyme metabolon on. Plasmalogen content and distribution in the sarcolemma of cultured neonatal rat myocytes.
FEBS Letters(), DOI: /(88) Margit Trotz, Lutz Hein, Karl Y. Hosteller. Solubilization and partial characterization of phospholipase A from rat heart sarcoplasmic by: Identification of plasmalogen as the major phospholipid constituent of cardiac sarcoplasmic reticulum Richard W.
Gross Biochemistry,24 (7), pp –Cited by: Electrocardiogram in the Normal Rat and Its Alteration with Experimental Coronary Occlusion SIGURD J. NORMANN Kinetics of Blood Protein Leakage in Inflammation. EMIL ASCHHEIM and ; BOOK REVIEWS.
Circulation Research. ;, originally published March 1, The synthesis and preclinical characterization of novel 4-(R)-methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridines that are potent and selective brain penetrant P2X7 antagonists are described.
Optimization efforts based on previously disclosed unsubstituted 6,7-dihydro-4H-triazolo[4,5-c]pyridines, methyl substituted 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazines, and several other series lead to Cited by: Neutrophils, a type of white blood cell, become hypersegmented, a change that can be found by examining a blood sample microscopically.
Because normal red blood cells have a lifetime in the circulation of approximately four months, it can take months for folate-deficient individuals to develop the characteristic megaloblastic anemia.
Cultured rat microglia express transcripts for K vK vand K v and LPS-induced activation triggers upregulation of K v expression. In vivo analysis of K DR channels expression has demonstrated that intracortical injection of 2 μg LPS triggered microglial activation as judged by Cited by: The liver is one of the largest organs in the body, weighing up to kg ( lb.) in adults .Interestingly, although this can constitute only ~% of body weight, the liver receives around 25% of the cardiac output .The liver is located in the upper right portion of the abdominal cavity, beneath the diaphragm and on top of the stomach, right kidney, and by: There was evidence for a concentration-related effect of UFP exposure on the percentage of blood monocytes.
In addition, monocyte expression of CD54 (ICAM-1) decreased after exposure in a concentration-response pattern (p=), with the greatest effect occurring at 0 and hours after exposure, and the differences resolved at 21 hours after.
SUMMARY Professional phagocytes (polymorphonuclear neutrophils and monocytes/macrophages) are a main component of the immune system. These cells are involved in both host defenses and various pathological settings characterized by excessive inflammation. Accordingly, they are key targets for immunomodulatory drugs, among which antibacterial agents are promising Cited by: Identification of KCC1, a member of the cation-Cl − cotransporter family Early functional characterization.
In the seventies, a Na +-independent K +-Cl − cotransport mechanism was formally identified for the first time in red blood cells (RBC) by three research groups [5,6,7].It was found to exhibit saturation kinetics and to be stimulated by cell swelling as well as N-ethylmaleimide, a Cited by: 1.
Until recently, the brain was studied almost exclusively by neuroscientists and the immune system by immunologists, fuelling the notion that these systems represented two isolated entities. However, as more data suggest an important role of the immune system in regulating the progression of brain aging and neurodegenerative disease, it has become clear that the crosstalk between these systems Cited by: We determined previously that lipoproteins of Borrelia burgdorferi stimulate inflammatory and anti-inflammatory cytokines (interleukin [IL]) in monocytes.
IL could have an effect on innate and acquired immune responses to B. burgdorferi and influence the magnitude of the infectious inoculum and disease outcome.
To understand the mechanism(s) of IL action during early infection Cited by: Sialic acid binding immunoglobulin-like lectin-7 (Siglec-7) is a trans-membrane receptor carrying immunoreceptor tyrosine based inhibitory motifs (ITIMs) and delivering inhibitory signals upon ligation with sialylated glycans.
This inhibitory function can be also targeted by several pathogens that have evolved to express sialic acids on their surface to escape host immune by: Human peripheral blood was obtained from normal donors with an approved protocol from the University of Washington.
Mononuclear cells were isolated from blood with lymphocyte separation medium (Mediatech, Inc., Herndon, VA) as described previously.
Monocytes/macrophages were subsequently isolated by plastic adherence for 18 h in Iscove's. Purpose Our preclinical work identified depletion of ATR as a top candidate for topoisomerase 1 (TOP1) inhibitor synthetic lethality and showed that ATR inhibition sensitizes tumors to TOP1 inhibitors.
We hypothesized that a combination of selective ATR inhibitor M (previously VX) and topotecan, a selective TOP1 inhibitor, would be tolerable and active, particularly in tumors Cited by: To determine the effect of endogenous IL on cytokine production, cells were stimulated with L-OspA or LPS in the presence or absence of a neutralizing rat anti-human IL antibody (Ab) (catalog no.
D; PharMingen) at 10, 20, and 40 μg/ml. Normal rat immunoglobulin G1 (catalog no. D) (PharMingen) was used as control.
Kinetics of leukocyte recruitment in thioglycollate-induced inflammation The number of cells present in the peritoneal cavity of animals injected with thioglycollate rose from ± × 10 6 at 4 h to ± × 10 7 on the 1st day and to ± × 10 7 on the 2nd day after thioglycollate by: 2.The treatment of glaucoma and other conditions relating to diseassed trabecular meshwork in the eye is effected by administration of macrophages and/or cytokines to the eye.
Increased levels of macrophages within the anterior chamber of the eye will at least partially clear obstruction of the trabecular meshwork and restore viability of trabecular cells in order to enhance release of aqueous Cited by: Molecular Approaches of Fungal Pathogenesis presents readers with an up-to-date compendium of research in the field of medical mycology.
This new volume measures the impact of genome projects, genetics, and molecular biology on the understanding of a diverse group of pathogenic fungi and explores the potential impact of vaccines and new therapeutic approaches to treatment.